Alaska Airlines will launch a daily nonstop service between Spokane International Airport and Paine Field-Snohomish County Airport in Everett on 4 November.
All Alaska flights at Paine Field are operated by Horizon Air with jet service using the Embraer 175 aircraft.
David Besse, manager of network planning at Alaska, said: "We believe this route will be very popular, easily connecting family and friends, workers and businesses, between two dynamic regions of the state.