At a distance of 8596 miles (13,834km), United Airlines new non-stop route from Sydney to Houston will be the airline's second longest flight after the Los Angeles to Singapore route launched in 2017.
The route will be serviced by the airline's Boeing 787-9 Dreamliners and will commence on January 18, 2018.
It will be the only non-stop service between Australia and Houston. Qantas operates a non-stop route to Texas from Australia; the Dallas to Melbourne route cover a distance of 13,804 km.
United currently operates services to Sydney non-stop from its West Coast hubs in Los Angeles and San Francisco.
Scott Kirby, president of United Airlines said: "This new route will serve more than 70 cities across North America making one-stop service to Sydney faster and more convenient than ever before.