Cathay Pacific has taken the decision to suspend its four-times weekly service from Dublin to Hong Kong from 7 November.
The decision by the Hong Kong-based carrier will last until 29 March 2020.
The move by Cathay Pacific comes after a "careful review of the current business environment".
The airline added in a statement: “This is a difficult decision to make, but also a necessary one in view of the commercial challenges we currently face. The Dublin and Hong Kong non-stop flight will resume on 30 March 2020.
"We are confident in the long-term prospect and strength of the traffic between Ireland, Hong Kong and the rest of Asia."
Cathay Pacific reporte near-40% drop in traffic into Hong Kong following the recent protests in Hong Kong which saw many flights cancelled.
Following this and the backlash surrounding some of the airline's decisions during the protests, the airline faced pressure from the Chinese government and saw departures of key staff members, including its chairman John Slosar as well as Rupert Hogg and Paul Loo who resigned as chief executive and chief customer commercial officer, respectively.